RAD-140 also called Testolone is a selective androgen receptor modulator. That means that RAD-140 have an androgenic effect on muscle tissue while having almost no effect on other tissues in the body. SARMs is of particular interest to researchers because they are selective about where they work. They mostly target muscle and bone tissues, and appear to have minimal effects on the prostate and other organs. The chemical structure of RAD-140 is very different from the structure of steroid hormones like testosterone. Thus, the pathways that convert testosterone into other hormones (like estrogen) cannot act on Testolone.
Based on a study in rats, some researchers have suggested that RAD-140 could activate receptors in injured regions of the brain. In the brains of rats given RAD140, MAPK activity increased, thus protecting neurons from damage .
This means that it will be anabolic on muscle tissues, increase protein synthesis and lead to lean muscle gain but will have less impact on other tissues in the body.
Due to its anti-estrogenic properties, it is expected to show fat loss properties as well. Since it is meant for increasing muscle mass, it will also increase your metabolic rate. This will lead to fat loss.
In order to experience these benefits, you would need to take a daily dosage of around 20 to 25 mg. As per research, the minimum dosage required to show results is around 10 mg per day. It has a half-life of around 3 to 4 hours which means that you will have to take it every day.
Being more anabolic also means that you are more likely to retain muscle mass as you are consuming more calories than your body needs to maintain its current weight. High-protein foods are anabolic because they take longer to digest, and thus you are less likely to overeat because of their satiating effect.
Androgens play an important role in protecting the brain. Moreover, they can reduce the risk of developing Parkinson’s disease. Androgens also have an anti-inflammatory effect on the brain. They can decrease the activity of microglia, which are macrophage cells that cause inflammation in the brain.
By reducing the activity of these cells, androgens can improve sleep quality and decrease stress. Furthermore, by increasing the level of serotonin and dopamine, androgens can improve the mood..