Ibutamoren is frequently used to increase lean body mass i.e. create bigger muscles. As previously mentioned, ibutamoren increases growth hormone levels and IGF-1. Both growth hormone and IGF-1, in turn, increase muscle mass, muscle strength, and reduce body fat. In 24 obese men, a two-month treatment (DB-RCT) with Ibutamoren increased lean mass, and transiently increased basal metabolic rate (BMR).
In a study (DB-RCT) in eight food-deprived healthy volunteers, MK-677 reversed diet-induced protein loss, that could cause muscle wasting. In 123 elderly patients with hip fracture, ibutamoren improved gait speed, muscle strength and reduced the number of falls (RCT).
Growth hormone increases tissue regeneration and wound healing, so MK-677 may help with these.